元慶應義塾大学所属の鈴木絵里子氏（梅澤一夫研究室）およびカリフォルニア大学ロサンゼルス校のBenjamin Bonavida研究室からの二つの論文に置いて、互いに類似した画像が多数認められ、不適切なデータの流用が疑われます。
Oncogene. 2007 Sep 13;26(42):6184-93. Epub 2007 Apr 9.
Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis.
1 Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA （カリフォルニア大学ロサンゼルス校）
2 Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama, Japan （慶應義塾大学 理工学部応用化学科）
PubPeerで最初の疑惑が指摘→ https://pubpeer.com/publications/FF771F6D16ADB90D7F8C11E5361A1F#fb7674
Unregistered Submission:
( April 14th, 2014 11:47pm UTC )
Oncogene. 2007 Sep 13;26(42):6184-93.
http://www.nature.com/onc/journal/v26/n42/pdf/1210448a.pdf
Oncogene誌の2007年の論文のFig.1aのAktの画像と、Badの画像、及び、Fig.2aのBadの画像の三つが、互いに類似しており、不適切なデータの流用が疑われます。
さらに、これらの画像は、Biomed Pharmacother誌の2006年の論文のFig.6Bの上段の p38の右側６レーン分の画像とも類似しており、不適切なデータ流用が疑われます。
(Figure 1a. Please compare the Akt and Bad panels. Please compare Bad panel in figure 2a with Bad panel in figure 1a.)
Oncogene誌の2007年の論文のFig.1bのβ-Actinの画像と、Fig.1cのβ-Actinの3,4,5レーン目の画像が、互いに類似しており、データの不適切な流用が疑われます。
(Please compare bands lanes 3,4 and 5 actin panel in figure 1c with bands actin panel in figure 1b.)
http://www.nature.com/onc/journal/v26/n42/pdf/1210448a.pdf
Oncogene誌の2007年の論文のFig.1aのAktの画像と、Badの画像、及び、Fig.2aのBadの画像の三つが、互いに類似しており、不適切なデータの流用が疑われます。
さらに、これらの画像は、Biomed Pharmacother誌の2006年の論文のFig.6Bの上段の p38の右側６レーン分の画像とも類似しており、不適切なデータ流用が疑われます。
(Figure 1a. Please compare the Akt and Bad panels. Please compare Bad panel in figure 2a with Bad panel in figure 1a.)
Oncogene誌の2007年の論文のFig.1bのβ-Actinの画像と、Fig.1cのβ-Actinの3,4,5レーン目の画像が、互いに類似しており、データの不適切な流用が疑われます。
(Please compare bands lanes 3,4 and 5 actin panel in figure 1c with bands actin panel in figure 1b.)
Int J Oncol. 2010 May;36(5):1299-307.
Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis.
Suzuki E (鈴木 絵里子) 1, Daniels TR, Helguera G, Penichet ML, Umezawa K (梅澤 一夫), Bonavida B.1 Department of Urology, School of Medicine, Keio University, Shinjuku-ku, Tokyo 165-8582, Japan. （慶應義塾大学医学部 泌尿器科学教室）
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732793/
Fig.2AのIM-9のβ-actinの画像が、8226のβ-actinの画像を180度回転させたものに類似しており、データの不適切な流用が疑われます。
Fig.2AのIM-9のβ-actinの画像が、8226のβ-actinの画像を180度回転させたものに類似しており、データの不適切な流用が疑われます。
Benjamin Bonavida
http://people.healthsciences.ucla.edu/institution/personnel?personnel_id=45426
PubPeerでBonavida氏の論文を検索→ https://pubpeer.com/search?q=bonavida
"Molecular mechanism of MART-1+/A*0201+ human melanoma resistance to specific CTL-killing despite functional tumor-CTL interaction"
Ali R Jazirehi, Stavroula Baritaki, Richard C Koya, Benjamin Bonavida, James S Economou, Cancer Res., 71 (2011)
https://pubpeer.com/publications/21159666
"Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis"
Eriko Suzuki, Tracy R Daniels, Gustavo Helguera, Manuel L Penichet, Kazuo Umezawa, Benjamin Bonavida, Int. J. Oncol., 36 (2010)
https://pubpeer.com/publications/20372806
"Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation"
Stavroula Baritaki, Alina Katsman, Devasis Chatterjee, Kam C Yeung, Demetrios A Spandidos, Benjamin Bonavida, J. Immunol., 179 (2007)
https://pubpeer.com/publications/17911631
Ali R Jazirehi, Stavroula Baritaki, Richard C Koya, Benjamin Bonavida, James S Economou, Cancer Res., 71 (2011)
https://pubpeer.com/publications/21159666
"Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis"
Eriko Suzuki, Tracy R Daniels, Gustavo Helguera, Manuel L Penichet, Kazuo Umezawa, Benjamin Bonavida, Int. J. Oncol., 36 (2010)
https://pubpeer.com/publications/20372806
"Regulation of tumor cell sensitivity to TRAIL-induced apoptosis by the metastatic suppressor Raf kinase inhibitor protein via Yin Yang 1 inhibition and death receptor 5 up-regulation"
Stavroula Baritaki, Alina Katsman, Devasis Chatterjee, Kam C Yeung, Demetrios A Spandidos, Benjamin Bonavida, J. Immunol., 179 (2007)
https://pubpeer.com/publications/17911631
"Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization"
Stavroula Baritaki, Kam Yeung, Michael Palladino, James Berenson, Benjamin Bonavida, Cancer Res., 69 (2009)
"Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis"
Ali R Jazirehi, Benjamin Bonavida, Mol. Cancer Ther., 3 (2004)
"Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab"
Ali R Jazirehi, Mario I Vega, Devasis Chatterjee, Lee Goodglick, Benjamin Bonavida, Cancer Res., 64 (2004)
"Development of rituximab-resistant lymphoma clones with altered cell signaling and cross-resistance to chemotherapy"
Ali R Jazirehi, Mario I Vega, Benjamin Bonavida, Cancer Res., 67 (2007)
"Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance"
Mario I Vega, Sara Huerta-Yepaz, Hermes Garban, Ali Jazirehi, Christos Emmanouilides, Benjamin Bonavida, Oncogene, 23 (2004)
"Nitric oxide sensitizes prostate carcinoma cell lines to TRAIL-mediated apoptosis via inactivation of NF-kappa B and inhibition of Bcl-xl expression"
Sara Huerta-Yepez, Mario Vega, Ali Jazirehi, Hermes Garban, Fumiya Hongo, Genhong Cheng, Benjamin Bonavida, Oncogene, 23 (2004)
"Raf Kinase Inhibitor Protein (RKIP) Blocks Signal Transducer and Activator of Transcription 3 (STAT3) Activation in Breast and Prostate Cancer"
Saad Yousuf, MeiLi Duan, Erika L. Moen, Sam Cross-Knorr, Kate Brilliant, Benjamin Bonavida, Theresa LaValle, Kam C. Yeung, Fahd Al-Mulla, Eugene Chin, Devasis Chatterjee, PLoS ONE(2014)
"Immunosensitization of melanoma tumor cells to non-MHC Fas-mediated killing by MART-1-specific CTL cultures"
P J Frost, L H Butterfield, V B Dissette, J S Economou, B Bonavida, J. Immunol., 166 (2001)
"Molecular mechanism of MART-1+/A*0201+ human melanoma resistance to specific CTL-killing despite functional tumor-CTL interaction"
Ali R Jazirehi, Stavroula Baritaki, Richard C Koya, Benjamin Bonavida, James S Economou, Cancer Res., 71 (2011)
"Proteasome inhibition blocks NF-κB and ERK1/2 pathways, restores antigen expression, and sensitizes resistant human melanoma to TCR-engineered CTLs"
Ali R Jazirehi, James S Economou, Mol. Cancer Ther., 11 (2012)
"The anti-CD20 mAb LFB-R603 interrupts the dysregulated NF-κB/Snail/RKIP/PTEN resistance loop in B-NHL cells: role in sensitization to TRAIL apoptosis"
Stavroula Baritaki, Loredana Militello, Graziella Malaponte, Demetrios A Spandidos, Margarita Salcedo, Benjamin Bonavida, Int. J. Oncol., 38 (2011)
鈴木 絵里子
学歴・職歴
2003年 慶應義塾大学理工学部応用化学科 卒業
2008年 慶應義塾大学理工学研究科理工学研究科基礎理工学専攻 博士課程修了
2006/04-2008/03 慶應義塾大学医学部泌尿器科特別研究助教
2010/04- 東京農工大学女性未来育成機構助教
現所属
農学部 応用生物科学科 農学府 連合農学研究科
研究分野・キーワード
細胞生物学： 細胞内シグナル伝達、薬剤感受性、炎症と癌、分子標的薬
受賞学術賞
国際学会論文発表奨励賞 (2007/11)
21世紀COEプログラムベストポスター賞 (2006/09)
筆頭著者論文
Int J Oncol. 2010 May;36(5):1299-307.
Inhibition of NF-kappaB and Akt pathways by an antibody-avidin fusion protein sensitizes malignant B-cells to cisplatin-induced apoptosis.http://www.ncbi.nlm.nih.gov/pubmed/20372806
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732793/
Bioorg Med Chem. 2009 Sep 1;17(17):6188-95. doi: 10.1016/j.bmc.2009.07.062. Epub 2009 Jul 29.
Preparation of conophylline affinity nano-beads and identification of a target protein.
http://www.ncbi.nlm.nih.gov/pubmed/19679484
http://www.sciencedirect.com/science/article/pii/S0968089609007172
Biomed Pharmacother. 2009 Jun;63(5):351-8. doi: 10.1016/j.biopha.2008.05.003. Epub 2008 Jun 20.
Inhibition of inflammatory mediator secretion by (-)-DHMEQ in mouse bone marrow-derived macrophages.
http://www.ncbi.nlm.nih.gov/pubmed/18635336
http://www.sciencedirect.com/science/article/pii/S0753332208001236
Biochem Biophys Res Commun. 2009 Feb 6;379(2):379-83. doi: 10.1016/j.bbrc.2008.12.065. Epub 2008 Dec 25.
Induction of histidine decarboxylase in macrophages inhibited by the novel NF-kappaB inhibitor (-)-DHMEQ.
Oncogene. 2007 Sep 13;26(42):6184-93. Epub 2007 Apr 9.
Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis.
Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis.
Biomed Pharmacother. 2006 Nov;60(9):578-86. Epub 2006 Sep 1.
Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin.
Inhibition of macrophage activation and phagocytosis by a novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin.
共著論文
Cancer Sci. 2010 Jan;101(1):216-23. doi: 10.1111/j.1349-7006.2009.01362.x. Epub 2009 Sep 14. Vitamin E succinate induced apoptosis and enhanced chemosensitivity to paclitaxel in human bladder cancer cells in vitro and in vivo.
http://www.ncbi.nlm.nih.gov/pubmed/19824995
http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2009.01362.x/abstract
Bioorg Med Chem Lett. 2009 Sep 15;19(18):5383-6. doi: 10.1016/j.bmcl.2009.07.120. Epub 2009 Jul 30.
Efficient synthesis of (+/-)-parasitenone, a novel inhibitor of NF-kappaB.
http://www.ncbi.nlm.nih.gov/pubmed/19666224
http://www.sciencedirect.com/science/article/pii/S0960894X09010932
J Immunol. 2008 May 1;180(9):6199-210. Inhibition of Yin Yang 1-dependent repressor activity of DR5 transcription and expression by the novel proteasome inhibitor NPI-0052 contributes to its TRAIL-enhanced apoptosis in cancer cells.
著書
臨床遺伝学'09 ―がんの遺伝子学― 鈴木絵里子、梅澤一夫 最新医学社 2009/09 251-260 2
がんの分子標的治療 鈴木絵里子、梅澤一夫 南山堂 2008/09 126-131 3
医学のあゆみ 鈴木絵里子、梅澤一夫 医歯薬出版 2008/03 65-69 4
バイオ医薬の開発技術とシーズ 鈴木絵里子、梅澤一夫 シーエムシー出版 2008/03 79-88 978-4-7813-0077-1
特許
（参考⇒http://kenkyu-web.tuat.ac.jp/Profiles/33/0003266/patents1.html）（写し）可溶性エポキシハイドラーゼ阻害剤 WO2012/115209
所属学会
研究発表、招待講演等一覧
http://kenkyu-web.tuat.ac.jp/Profiles/33/0003266/meeting_achieve1.html（写し）梅澤 一夫（愛知医科大学医学部分子標的医薬探索講座・教授）
愛知医科大学医学部分子標的医薬探索講座ホームページ
梅澤ラボ・チャンネル
http://www.umelab.net/index.html（写し）
慶應義塾大学 理工学部 応用化学科 生物化学研究室ホームページ
梅澤 一夫(Kaken 科学研究費助成事業データベース）
http://kaken.nii.ac.jp/d/r/70114402.html
ウメザワ カズオ Umezawa, Kazuo 研究者番号：70114402 研究者リゾルバーID：1000070114402
http://kaken.nii.ac.jp/d/r/70114402.html
ウメザワ カズオ Umezawa, Kazuo 研究者番号：70114402 研究者リゾルバーID：1000070114402
